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第一部分 奋斗历程1

陈志南院士简介3

锲科学之难题而不舍 持学术之精神以永恒5

陈志南院士主要学术职务8

第二部分 学术贡献9

一、陈志南院士的主要学术论文11

Randomized Trial of[131I] Metuximab in Treatment of Hepatocellular Carcinoma After Percutaneous Radiofrequency Ablation11

HAb18G/CD147 Promotes Cell Motility by Regulating Annexin Ⅱ-Activated RhoA and Rac1 Signaling Pathways in Hepatocellular Carcinoma Cells17

A Randomized Controlled Trial of Licartin for Preventing H epatoma Recurrence After Liver Transplantation31

HAb18G/CD147 Promotes Activation of Hepatic Stellate Cells and is a Target for Antibody Therapy of Liver Fibrosis41

CD147 Induces UPR to Inhibit Apoptosis and Chemosensitivity by Increasing the Transcription of Bip in Hepatocellular Carcinoma52

HAb18G/CD147 Promotes Epithelial-Mesenchymal Transition through TGF-β Signaling and is Transcriptionally Regulated by Slug67

Leukocyte Telomere Length Predicts Overall Survival in Hepatocellular Carcinoma Treated with Transarterial Chemoembolization87

Hypoxia Upregulates CD147 through a Combined Effect of HIF-1α and Spl to Promote Glycolysis and Tumor Progression in Epithelial Solid Tumors97

GWAS-Identified Colorectal Cancer Susceptibility Locus Associates with Disease Prognosis111

Characterization of Basigin Isoforms and the Inhibitory Function of Basigin-3 in Human Hepatocellular Carcinoma Proliferation and Invasion121

Crystal Structure of HAb18G/CD147139

Overexpression of HAb18G/CD147 Promotes Invasion and Metastasis via α3β1 Integrin Mediated FAK-Paxillin and FAK-PI3K-Ca24Pathways151

A Protein Chip Approach for High-Throughput Antigen Identification and Characterization161

Extracellular Membrane Proximal Domain of HAb18G/CD147 Binds to Metal Ion-dependent Adhesion Site（MIDAS）Motif of Integrin β1 to Modulate Malignant Properties of Hepatoma Cells172

Comprehensive Pathway-Based Interrogation of Genetic Variations in the Nucleotide Excision DNA Repair Pathway and Risk of Bladder Cancer189

Longer Leukocyte Telomere Length Predicts Increased Risk of Hepatitis B Virus-Related Hepatocellular Carcinoma200

Involvement of HAb18G/CD147 in T Cell Activation and Immunological Synapse Formation210

RNA-Seq Analyses Generate Comprehensive Transcriptomic Landscape and Reveal Complex Transcript Patterns in Hepatocellular Carcinoma223

A Meta-Analysis of Array-CGH Studies Implicates Antiviral Immunity Pathways in the Development of Hepatocellular Carcinoma239

HAb18G/CD147 Functions in Invasion and Metastasis of Hepatocellular Carcinoma250

The Differential Expressions of 78-kDa Glucose-Regulated Protein of Infiltrating Plasma Cells in Peripheral Joints with the Histopathological Variants of Rheumatoid Synovitis262

Construction of RecombinantNewcastle Disease Virus Italien Strain for Oncolytic Virotherapy of Tumors272

Promoter Hypomethylation Up-Regulates CD147 Expression through Increasing Sp1 Binding and Associates with Poor Prognosis in Human Hepatocellular Carcinoma284

Expression of CD147 on Monocytes/Macrophages in Rheumatoid Arthritis:Its Potential Role in Monocyte Accumulation and Matrix Metalloproteinase Production299

Genetic Polymorphisms in Pre-microRNA Genes as Prognostic Markers of Colorectal Cancer311

HAb18G(CD147),a Cancer-associated Biomarker and Its Role in Cancer Detection324

HAb18G/CD147 Inhibits Starvation Induced Autophagy in Human Hepatoma Cell SMMC7721 with an Involvement of Beclin 1 Down-Regulation335

Annexin Ⅱ Promotes Invasion and Migration of Human Hepatocellular Carcinoma Cells in vitro via its Interaction with HAb18G/CD147345

Transcription Factor Sp1 Regulates Expression of Cancer-Associated Molecule CD147 in Human Lung Cancer356

CD147 in Human Lung Cancer356

Upregulation of HAb18G/CD147 in Activated Human Umbilical vein Endothelial Cells Enhances the Angiogenesis367

Contribution of Cyclophilin A to the Regulation of Inflammatory Processes in Rheumatoid Arthritis377

Optimal Design of Ig 5′Primers for Construction of Diverse Phage Antibody Library Established to Select Anti-HAb18GEF and Anti-DOTA-Y Fabs for Hepatoma Pretargeting RIT387

Targeting Radioimmunotherapy of Hepatocellular Carcinoma with Iodine(131I)Metuximab Injection:Clinical Phase Ⅰ/ⅡTrials406

Radioimmunotherapy of H umancolon Cancer Xenografts by Using 131I Labeled-CAb F1(ab′)2417

A Novel Antibody Fragment Targeting HAb18G/CD147 with Cytotoxicity and Decreased Immunogenicity425

HAb18G/CD147 Cell Cell Contacts Confer Resistance of a HEK293 Subpopulation to Anoikis in an E-Cadherin-Dependent Manner436

Dimerization is Essential for HAb18G/CD147 Promoting Tumor Invasion via MAPK Pathway449

Characterization of the Genome Sequence of an Oncolytic Newcastle Disease Virus Strain Italien457

High Efficiency Reconstitution of a Human Mouse Chimeric Fab of CAb-1 Antibody Specific to Human Colon Cancer467

New Strategy for Large-scale Preparation of the Extracellular Domain of Tumor-Associated Antigen HAb18G/CD147(HAb18GED)478

抗人肝细胞癌单克隆抗体的产生及其相应抗原P60的免疫组化定位研究487

二、陈志南院士的主要学术著作491

抗体分子与肿瘤491

激光扫描共聚焦显微镜技术499

重组抗体500

细胞工程502

工程细胞生物学504

三、陈志南院士学术年表509

陈志南院士学术论文目录509

陈志南院士主要著作目录532

陈志南院士的专利授权目录533

陈志南院士主要获奖目录535

第三部分 人生风采537

科研教学539

学术交流542

珍贵留影545