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呼吸系统
  • (英)戴维斯,(英)穆瑞斯主编 著
  • 出版社: 北京:北京大学医学出版社
  • ISBN:9787565901171
  • 出版时间:2011
  • 标注页数:171页
  • 文件大小:79MB
  • 文件页数:180页
  • 主题词:呼吸系统疾病-医学院校-教材-英文

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图书目录

1 INTRODUCTION1

Introduction2

What is respiration?2

The need for respiration2

Diffusion in respiration and the circulation3

Timing in the circulation and respiration3

Basic science of respiration3

Drugs9

2 STRUCTURE OF THE RESPIRATORY SYSTEM,RELATED TO FUNCTION11

Introduction12

The upper airways12

The intrathoracic airways15

Blood vessels18

Pulmonary hypertension18

The lymphatics19

The nerves19

Gross structure of the respiratory system19

Pleurisy20

The diaphragm and chest wall20

How breathing is brought about22

Embryology23

Air-conditio ning24

Metabolic activity26

Metabolism of circulating biologically active substances27

Non-respiratory functions27

3 ELASTIC PROPERTIES 0F THE RESPIRATORY SYSTEM29

Introduction30

Intrapleural pressure(Ppl)30

Static lung compliance(CL)31

The effect of disease32

The physical basis of lung compliance32

4 AIRFLOW IN THE RESPIRATORY SYSTEM41

Introduction42

How airflow is brought about42

The nature of airflow43

The major determinant of flow-radius43

Airways resistance and obstructive pulmonary disease43

The clinical situation45

Sites of airways resistance46

Asthma and airways smooth muscle48

Bronchomotor tone49

Pharmacological treatment of asthma50

Clinical definitions50

Bronchitis and mucus52

Emphysema and radial traction53

Intrapleural pressure and cough54

Clinical tests for changes in resistance57

Work of breathing57

5 VENTILATION OF THE RESPIRATORY SYSTEM:THE IMPORTANCE OF ITS LACK OF UNIFORMITY IN DISEASE61

Introduction62

Spirometric abnormalities in disease63

Uneven distribution64

Dead space64

Alveolar dead space in disease65

The Bohr equation66

Factors affecting physiological dead space68

Alveolar ventilation and respiratory exchange68

The alveolar gas equation69

Distribution of inspired gas69

Other factors influencing distribution72

6 GAS EXCHANGE BETWEEN AIR AND BLOOD:DIFFUSION77

The path from air to tissue78

Lung disease and diffusion79

Fick's Law of Diffusion79

Measuring transfer factor82

Treating diffusion difficulties83

Carbon dioxide and other gases83

7 THE PULMONARY CIRCULATION:BRINGING BLOOD AND GAS TOGETHER85

The functions of the pulmonary circulation86

The anatomy of the pulmonary circulation86

Matching ventilation and perfusion89

Distribution of blood flow through the lungs89

Regional differences in ventilation in the lungs94

Ventilation/perfusion matching and its effect on blood O2 and CO2 content95

Shunt97

8 CARRIAGE OF GASES BY THE BLOOD AND ACID/BASE BALANCE99

Introduction100

Oxygen transport100

Dissolved oxygen:do we really need Hb and why keep it in red cells?108

Carbon dioxide transport109

Acid-base balance113

9 CHEMICAL CONTROL OF BREATHING119

Introduction120

Oxygen lack120

Carbon dioxide excess125

10 NERVOUS CONTROL OF BREATHING129

Introduction130

The rhythm generator131

Pattern of breathing in COPD132

The respiratory ' centres'133

The medullary groups133

Conscious control of breathing134

Respiratory muscle innervation135

Neuromuscular disorders137

Vagal reflexes137

Dyspnoea140

Other reflexes140

11 LUNG FUNCTION TESTS:MEASURING DISABILITY143

Introduction144

Spirometry144

Flow measurements145

Plethysmography145

Lung mechanics146

Transfer factor(diffusing capacity)147

Blood gases148

Gas washouts148

Exercise testing150

Challenge tests151

Appendix:some basic science153

Glossary159

Index165

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